CVE-2026-31973

High

Description

SAMtools is a program for reading, manipulating and writing bioinformatics file formats. Starting in version 1.17, in the cram-size command, used to write information about how well CRAM files are compressed, a check to see if the `cram_decode_compression_header()` was missing. If the function returned an error, this could lead to a NULL pointer dereference. Exploiting this bug causes a NULL pointer dereference. Typically this will cause the program to crash. Versions 1.23.1, 1.22.2 and 1.21.1 include fixes for this issue. There is no workaround for this issue.

SeverityHigh
CVSS7.5
Exploit probability—
ProductSamtools
PublishedMar 18, 2026
First seenMar 18, 2026

How to fix

Update
  • samtools samtools1.22.2 or later

Affected products

ProductAffected versionsFixed in
samtools samtools1.17 ≤ v ≤ 1.21.1, 1.22 ≤ v < 1.22.2, 1.231.22.2

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